ֱ

Integrative Systems Biology
ISB

Research group for Integrative systems biology (ISB) at Linköping University.

In the integrative systems biology group we aim towards being the world leading group in the unravelling of systems-level mechanistic insights, using inter-connected M4 models for decision support in pharma and P4 medicine – thereby making a positive change in society.

We do modelling in collaboration with a large number of experimental groups, focusing on different biological systems. In these projects, our collaborators serve as the biological experts, and we are the experts on the modelling. This means that our collaborators do not need to have extensive knowledge about modelling.

We are currently working on modelling of e.g. insulin signalling and lipolysis in adipocytes; nutrient fluxes on a whole-body scale; interpretation of fMRI signals in brain, and quantification of liver- and heart-diseases using MRI; modelling as an aid for improved drug development; and modelling to replace animal experiments.

In the systems biology group, we are constantly looking for new collaborations; be it students for internships, experimentalists for new projects or companies for making our insights of use for the public. Feel free to contact us if you want to know more!

Research projects

En man och en kvinna står framför tre dataskärmar.

M4-HEALTH: a new model for health using digital twins and AI

M4-HEALTH is a network that combines 16 Swedish universities together with over 100 companies and other organizations into a new ecosystem for health.

A man sits and analyzes a sample in a beaker.

How to solve murders using postmortem metabolomics and artificial intelligence

Successful efforts from this research environment will be implemented into routine case work and will aid police work in providing investigative leads and new tools to expand objective forensic evidence.

Blurry illustration, silhouette of a head in blue monochrome tones.

STRATIF-AI – Digital twins for stroke

The STRATIF-AI project is about continuous stratification for improved prevention, treatment, and rehabilitation of stroke patients using digital twins and AI. It is a four-year research project funded by Horizon Europe.

Finished projects

Publications

2026

Alejandro Garcia-Rudolph, Rocio Sanchez-Carrion, Katryna Cisek, Thi Nguyet Que Nguyen, Claudia Teixido-Font, Eloy Opisso, Rory O'Connor, Gelu Onose, Gunnar Cedersund (2026) NeuroRehabilitation (Article in journal)
Elin Nyman, Rasmus Magnusson, Tomas Strömberg, Carl Johan Östgren, Sara Bergstrand, Hanna Jonasson (2026) Biology of Sex Differences, Vol. 17, Article 138 (Article in journal)
Gustav Magnusson, Alex A Bhogal, Charalampos Georgiopoulos, Gunnar Cedersund, Lovisa Tobieson, Maria Engström, Anders Tisell (2026) Journal of Cerebral Blood Flow and Metabolism (Article in journal)
Ralph E. C. Monte, Rasmus Magnusson, Carl Soderberg, Henrik Green, Albert Elmsjo, Elin Nyman (2026) Scientific Reports, Vol. 16, Article 11607 (Article in journal)
Henrik Podéus Derelöv, Christian Simonsson, Gerd Jakobsson, Robert Kronstrand, Elin Nyman, William Lövfors, Gunnar Cedersund (2026) Scientific Reports, Vol. 16, Article 9336 (Article in journal)
Rasmus Magnusson, Carl Soderberg, Liam Ward, Jenny Arpe, Fredrik Kugelberg, Albert Elmsjö, Henrik Green, Elin Nyman (2026) Nature Communications, Vol. 17, Article 1504 (Article in journal)

2025

Nilmini Wickramasinghe, Nalika Ulapane, Yuxin Zhang, Paul Jansons, Gunnar Cedersund, Ralph Maddison (2025) Sensors, Vol. 26, Article 82 (Article in journal)
Kajsa Tunedal, Tino Ebbers, Gunnar Cedersund (2025) Computers in Biology and Medicine, Vol. 188, Article 109878 (Article in journal)
Alejandro Garcia-Rudolph, Mark Andrew Wright, Claudia Teixido-Font, Rocio Sanchez-Carrion, Gunnar Cedersund, Eloy Opisso (2025) Topics in Stroke Rehabilitation (Article, review/survey)
Nicolas Sundqvist, Henrik Podéus, Sebastian Sten, Maria Engström, Salvador Dura-Bernal, Gunnar Cedersund (2025) Computers in Biology and Medicine, Vol. 197, Article 111014 (Article in journal)

Latest student publications

Research group

Organisation